Structural basis for termination of AIM2-mediated signaling by p202
نویسندگان
چکیده
منابع مشابه
Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling.
The HIN-200 family of proteins play significant roles in inflammation-related processes. Among them, AIM2 (absent in melanoma 2) and IFI16 (γ-interferon-inducible protein 16) recognize double-stranded DNA to initiate inflammatory responses. In contrast, p202, a mouse interferon-inducible protein containing two HIN domains (HINa and HINb), has been reported to inhibit Aim2-mediated inflammatory ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2013
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2013.52